Vitamin C vs Pseudomonas Aeruginosa

Bactericidal Action of Ascorbic Acid on Pseudomonas Aeruginosa: Alteration of Cell Surface as a Possible Mechanism (Vita C as Catalyst)

Abstract

Neutralised ascorbic acid is found to exert a strong bactericidal action on Pseudomonas aeruginosa suspended in isotonic phosphate buffer at pH 7.1. Both the bactericidal and bacteriostatic action of ascorbic acid are antagonised by magnesium ions. In the absence of complex formation between magnesium and ascorbic acid it is concluded that ascorbic acid acts by competing with the magnesium binding sites in the cell wall, cell membrane or ribosomes. Using the chequer-board titration method the synergistic action of ascorbic acid and erythromycin is determined; such a potentiation of erythromycin is also adversely affected by magnesium ions. P. aeruginosa cells, washed and suspended in isotonic phosphate buffer containing ascorbic acid, became increasingly susceptible to the action of polymyxin, erythromycin, chloramphenicol, neomycin and tetracycline. It is suggested that ascorbic acid alters the cell surface to render it increasingly permeable to these antibiotics.

© 1978 S. Karger AG, Basel

http://www.karger.com/Article/PDF/237777
http://www.ncbi.nlm.nih.gov/pubmed/207492

Synergic interaction between ascorbic acid and antibiotics against Pseudomonas aeruginosa

Luciana CursinoI, II; Edmar Chartone-SouzaI; Andréa Maria Amaral
NascimentoI, *

IDepartamento de Biologia Geral; Universidade Federal de Minas Gerais;
Avenida Antônio Carlos, 6627; 31270-901; Belo Horizonte - MG - Brazil
IIDepartamento de Genética ESALQ/USP; Av. Pádua Dias, 11; 1340-097;
Piracicaba - SP - Brazil

Abstract

Studies were carried out on in vitro combination of ascorbic acid (AA)
with six antibiotics against 12 multi-resistant Pseudomonas aeruginosa
isolates. Synergic activity was detected with AA chloramphenicol,
kanamycin, streptomycin and tetracycline. Indifference was observed to
any antibiotics and antagonism only for chloramphenicol. Results
indicated that multiresistant P. aeruginosa was affected by combination
of AA and antibiotics. Future research on ascorbic acid-antimicrobial
interactions may find new methods to control strains of multiresistant
P. aeruginosa.

Key words: Ascorbic acid, antibiotic, synergy, Pseudomonas aeruginosa

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000300007&lng=en&nrm=iso&tlng=en

Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages

http://www.hindawi.com/journals/mi/2014/426740/


IV vitamin C article courtesy of Tim Ewer, Gerald Lewis and ACNEM

This article on use of intravenous vitamin C was originally published in The Journal of the Australian College of Nutritional and Environmental Medicine, Volume 30 No 1, April 2011.

http://www.holistic-doc-pain-support.com/IV-vitamin-C.html

How Vitamin C Fights Cancer: Scientific Explanation and Procedure by Riordan Clinic

Note: I am not a fan of Vitamin C, but this is an attempt to list out all alternative treatment available for cancer cure.

"All truth passes through three stages: First, it is ridiculed; Second, it is violently opposed; Third, it is accepted as being self-evident"

Arthur Schopenhaeur

Details Scientific Presentation and Research by
Dr Ron Hunninghake of Riordan Clinic

Vitamin C Paradox

Vitamin C is always an anti-oxidant. At low dosages, it acts purely as an anti-oxidant. However at high doses, Vitamin C are both simultaneously:

• ANTI-OXIDANT and
• PRO-OXIDANT

Once acted as PRO-OXIDANT at high doses, Vitamin C will be similarly as potent but smart unlike of SYNTHETIC CHEMOTHERAPY AGENT in which role to increase the OXIDATIVE STRESS to the target cancer cells.

"Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo (living body)" Proceedings of National Academy of Science, May 14 2007 | Vol. 104 | No. 21 | 8749-8754 | National Institute of Health

Vitamin C Chemotherapy (Hydrogen Peroxide > Hydroxyl Radicals)

Vitamin C should be used in conjunction with the conventional chemo, radiation or surgery treatment in order to get the best effect (According to Riordan Clinic). The smaller the size of tumor cells mass, the more effective Vitamin C Pro-Oxidant (Hydroxyl Radicals) ability to kill the remaining cancer cells.  However Conventional Chemo is highly toxic to healthy cells and body immune system.

The beauty is, when used SIMULTANEOUSLY, Vitamin C (as anti-oxidant and pro-oxidant) will significantly reduce side effects contributed by the conventional treatment.

The correct doses of Vitamin C will directly speed up Tumor Cytotoxicity (the quality of being toxic to tumor cells). High dose intravenous Vitamin C generates hydroxyl radicals which can damage cells.

However healthy cells are able to neutralize peroxide toxicity with high availability of Catalase (peroxide suppression enzyme). This leaves tumor cells which are normally low in Catalase, to be vulnerable to peroxide.

Thus Vitamin C is a natural chemotherapy, smart enough to select the target cells to kill.

Effect of Oxidation to Cancer Cells

Hydroxyl Radical is very Toxic to Cancer Cells

Vita C Pro Oxidant Effect

Redox Cycling with High Dose

Intravenous Vitamin C

Potent Ascorbate Concentration Doses
to kill Cancer Cells (350-400mg/dL)

The green line shows Hydroxyl Radicals cannot kill
cancer cells reside in dense hollow fiber (thicker mass)

Next...

Where to get IV Vitamin C ?

Which Doctor or Clinic is willing to take the risk?

Cancer Cure: IV Vitamin C Curing Cancer and Infections
Living Proof Vitamin C Miracle Cure (Alan Smith - H1N1/Swine Flu)
Vitamin C Intravenous - The Riordan Protocal
Vitamin C Antitoxin - Thomas Levy

Disclaimer: Please listen carefully to the full video presentation. Use the above information with your own discretion.